Human SIRPa Protein; hFc-His Tag
Product Sizes
10μg
PME100009-10UG
50μg
PME100009-50UG
100 μg
PME100009-100UG
About this Product
- SKU:
- PME100009
- Additional Names:
- SHPS1;SIRPA;CD172A;BIT;MFR;MYD1;P84;PTPNS
- Buffer:
- sterile pbs
- CE/IVD:
- RUO
- Conjugate:
- Unconjugated
- Extra Details:
- Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a); Macrophage fusion receptor; MyD-1 antigen; Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84; is a member of the SIRP family; and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6; PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons; neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion; growth factors or insulin and mediates negative regulation of phagocytosis; mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
- Formulation:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Immunogen:
- SIRPa
- Molecular Weight:
- The protein has a predicted molecular mass of 70-98 kDa after removal of the signal peptide.
- Physical State:
- Lyophilized
- Purity:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Purification:
- Affinity Purified
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- DIMA Biotechnology Ltd
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Target:
- SIRPa
- SIRPa(Glu31-Tyr373) hFc(Glu99-Ala330) 6×His tag:
- SIRPa(Glu31-Tyr373) hFc(Glu99-Ala330) 6×His tag
- Manufacturer's Data Sheet:human-sirpa-protein-hfc-his-tag
