Biotinylated Human B7-1 / CD80 Protein, Fc,Avitag[TM] (MALS verified)

Product Size(s)

25 ug

£394.00

B71-H82F2-25UG

200 ug

£1665.00

B71-H82F2-200UG

Academic Pricing

Please contact us for academic pricing.

About this Product

SKU:: B71-H82F2
Additional Names:: B7|B7.1|B7-1|BB1|CD28LG|CD28LG1|CD80|LAB7
Buffer:: Tris with Glycine, Arginine and NaCl, pH7.5
Conjugate:: Biotin
Extra Details:: B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20 - 100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-K KappaB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
Molecular Weight:: 52.3 kDa
Physical State:: Powder
Shipping Conditions:: Ambient
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Type:: Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein

Epitope Tag:: AviTag™, Fc Tag
Long Description:: B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20 - 100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-K KappaB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
Accession:: NP_005182.1

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