Biotinylated Human B7-1 / CD80 Protein, Fc,Avitag[TM] (MALS verified) Citation Available Product Size(s) 25 ug £394.00 B71-H82F2-25UG Add to order Added to order 200 ug £1665.00 B71-H82F2-200UG Add to order Added to order Academic Pricing Please contact us for academic pricing. Contact Us About this Product SKU: B71-H82F2 Additional Names: B7|B7.1|B7-1|BB1|CD28LG|CD28LG1|CD80|LAB7 Buffer: Tris with Glycine, Arginine and NaCl, pH7.5 Conjugate: Biotin Extra Details: B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20 - 100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-K KappaB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas. Molecular Weight: 52.3 kDa Physical State: Powder Shipping Conditions: Ambient Storage Conditions: -20[o]C Supplier: ACRO Biosystems Type: Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein Epitope Tag: AviTag™, Fc Tag Long Description: B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20 - 100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-K KappaB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas. Accession: NP_005182.1 Biotinylated Human B7-1, Fc,Avitag on SDS-PAGE under reducing (R) and under non-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. Immobilized Human CTLA-4, Fc Tag (Cat. No. CT4-H5255) at 5 ug/mL (100 uL/well) can bind Biotinylated Human B7-1, Fc,Avitag (Cat. No. B71-H82F2) with a linear range of 0.6-9.8 ng/mL (QC tested). Immobilized Human PD-L1, Fc Tag (Cat. No. PD1-H5258) at 10 ug/mL (100 uL/well) can bind Biotinylated Human B7-1, Fc,Avitag (Cat. No. B71-H82F2) with a linear range of 0.156-5 ug/mL (Routinely tested). Need Help? View product citations for antibodies B71-H82F2 on CiteAb