NLS-Cas12a Nuclease (MALS verified)
Product Sizes
50 ug
£400.00
CAA-L5149-50UG
100 ug
£483.00
CAA-L5149-100UG
500 ug
£742.00
CAA-L5149-500UG
About this Product
- SKU:
- CAA-L5149
- Additional Names:
- cas12a|Cpf1|CRISPR-associated endonuclease Cas12a|CRISPR-associated endonuclease Cpf1
- Buffer:
- 20 mM NaAC, 500 mM NaCl, 0.1 mM EDTA, 0.1 mM TCEP, pH6.0
- Extra Details:
- Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated endonuclease from Lachnospiraceae bacterium, Cas12a, also known as Cpf1, is a 1200-1500 amino-acids long monomeric protein that belongs to the CRISPR/Cas system , an adaptive immune system of prokaryotes that has now become a powerful tool for genome editing. CRISPR/Cas12a belongs the class II (type 5) of the CRISPR/Cas system that is defined by a single-subunit effector. Cas12a has recently emerged as an alternative for Cas9, due to its distinct features such as the ability to target T-rich motifs, no need for trans-activating crRNA, inducing a staggered double-strand break and potential for both RNA processing and DNA nuclease activity. In addition, Cas12a is able to process more structured pre-CRISPR/RNA(crRNA) molecules into mature crRNAs which allows the possibility to use both mature or pre-crRNA for genome editing purposes. All these features make the CRISPR/Cas12a system a valuable genome-engineering tool. CRISPR-Cas12a has been successfully used to edit genomes in many mammalians cells and plants.
- Molecular Weight:
- 147.6 kDa
- Physical State:
- Liquid
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes