CCL-11
Product Sizes
100 ug
£674.12
103-M321-100UG
About this Product
- SKU:
- 103-M321
- Additional Names:
- Ccl11 chemokine (C-C motif) ligand 11; Scya11; eotaxin
- Application:
- Block/Inhibit/Neutralise, Immunohistochemistry, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 7H5
- Clonality:
- Monoclonal
- Extra Details:
- CCL11 is a potent eosinophil chemoattractant that was originally purified from bronchoalveolar lavage fluid of guinea pigs sensitized by aerosol challenge with ovalbumin. Mouse CCL11 cDNA encodes a 97 amino acid (aa) precursor protein from which the aminoterminal 23 aa are cleaved to generate the 74 aa mature mouse CCL11. At the protein sequence level, mature mouse CCL11 is approximately 60% identical to mature human and guinea pig CCL11. In addition, mouse CCL11 also shows high aa sequence identity to members of the MCP family. Mouse CCL11 is chemotactic for eosinophils, but not mononuclear cells or neutrophils. CCL11 mRNA is expressed in a variety of tissues. The expression of CCL11 mRNA is induced in cultured endothelial cells in response to IFNG Gamma. In addition, CCL11 mRNA is also induced in response to the transplantation of IL4secreting tumor cells. The CC chemokine receptor 3 (CCR3) has been identified as a specific human CCL11 receptor.
- Formulation:
- lyophilized
- Host:
- Rat
- Immunogen:
- recombinant mouse CCL-11
- Isotype:
- IgG2
- Purification:
- Protein G/A chromatography
- Reactivities:
- Mouse
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody