Apolipoprotein AI, Low Endotoxin Level, (ApoA1-LEL)
Product Sizes
0.5 mg
16-16-120101-LEL-0.5MG
1 mg
16-16-120101-LEL-1MG
10 mg
16-16-120101-LEL-10MG
About this Product
- SKU:
- 16-16-120101-LEL
- Additional Names:
- ApoAI|In Vitro Diagnostic, Cardiovascular Research, ALS, Diabetes, Cell Based Assays, Animal Studies
- Application:
- Cell-based/Functional Assay
- Buffer:
- Frozen in 10 mM NH4HCO3, pH 7.4
- CE/IVD:
- RUO
- Extra Details:
- Apolipoprotein AI (Apo AI), constituting 75% of HDL-associated apolipoproteins, is a critical for reverse cholesterol transport (RCT), mediating cholesterol efflux from peripheral tissues to the liver. As the primary structural component of HDL, Apo AI stabilizes discoidal HDL particles, activates lecithin-cholesterol acyltransferase (LCAT) to esterify cholesterol, and facilitates HDL maturatioN. Its anti-inflammatory properties include blocking T-cell-monocyte interactions, reducing TNF-A Alpha and IL-1B Beta production, and neutralizing oxidized LDL. Normal plasma levels range from 90-130 mg/100 mL, with concentrations inversely correlating with coronary heart disease (CHD) risk. Deficiencies in Apo AI underlie Tangier disease, characterized by near-absent HDL, cholesterol-laden macrophages, and premature atherosclerosis. Mutations like APOA1 p.Leu202Arg cause systemic amyloidosis, leading to cardiac and renal dysfunction. Reduced Apo AI levels also associate with insulin resistance, impaired B Beta-cell function, and diabetes progression. Conversely, Apo AI overexpression enhances macrophage-specific RCT, attenuating atherosclerosis.
- Formulation:
- Frozen in 10 mM NH4HCO3, pH 7.4
- Molecular Weight:
- 28,000 Da
- Physical State:
- Frozen
- Purity:
- ≥95%
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Dry Ice
- Source:
- Source human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Native
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