S-100aa, Bovine
Product Sizes
0.1 mg
16-BR-190801-BOVINE-0.1MG
About this Product
- SKU:
- 16-BR-190801-BOVINE
- Additional Names:
- Alzheimer's, Stroke, In Vitro Diagnostics, Brain Injury, Cancer, Inflammation|S-100aa Calcium Binding Protein, S-100 protein alpha chain S-100 protein subunit alpha
- Buffer:
- Lyophilized from 50 mM Tris-HCl, pH 7.5, 50 mM NaCl, 100 uM DTT
- CE/IVD:
- RUO
- Extra Details:
- S-100A AlphaA Alpha (S-100aa) from bovine brain is a low molecular weight, cytoplasmic, calcium-binding protein belonging to the S100 family, which is characterized by the presence of EF-hand calcium-binding motifs. Structurally, S-100A AlphaA Alpha is a homodimer composed of two alpha subunits, distinct from the beta-beta (S-100B BetaB Beta) and alpha-beta (S-100A AlphaB Beta) forms found in nervous tissue. Its conformation and function are modulated by calcium and, to a lesser extent, by other ions such as potassium, reflecting its role in responding to changes in the cellular environment. Functionally, S-100A AlphaA Alpha participates in the regulation of various intracellular activities, including cell proliferation, differentiation, and cytoskeletal dynamics, often through interactions with target proteins in a calcium-dependent manner. It is predominantly expressed in astroglial cells and is involved in maintaining neural homeostasis. Aberrant expression or release of S-100 proteins, including S-100A AlphaA Alpha, has been linked to neurological diseases such as Alzheimer's disease, stroke, and traumatic brain injury, where their serum levels serve as sensitive biomarkers of brain damage and disease progression. In research and clinical applications, S-100A AlphaA Alpha is widely used as a marker for central nervous system injury and as a tool for studying calcium-mediated signaling pathways in neurobiology. Its measurement aids in diagnosis, prognosis, and monitoring of neurological disorders and has potential utility in cancer and inflammatory disease research due to the broader roles of S100 proteins in cell regulation and disease pathogenesis.
- Formulation:
- Lyophilized from 50 mM Tris-HCl, pH 7.5, 50 mM NaCl, 100 uM DTT
- Molecular Weight:
- 6,500 Da
- Physical State:
- Lyophilized
- Purity:
- ≥95%
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Blue Ice
- Source:
- Prepared from tissue collected in the contiguous United States from animals under 30 months of age at a USDA-inspected facility. Animals were inspected ante mortem and found free from obvious signs of infectious and contagious diseases.
- Storage Conditions:
- -20[o]C
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Native
