Transferrin (HOLO), Bioprocessing Grade
Product Sizes
100 mg
16-16-032001-BPG-100MG
1000 mg
16-16-032001-BPG-1000MG
5000 mg
16-16-032001-BPG-5000MG
About this Product
- SKU:
- 16-16-032001-BPG
- Additional Names:
- Biomanufacturing, ELISA, Antisera Production, In Vitro Diagnostic, Protein Chemistry Research, Drug Delivery research, Iron Metabolism, Infection|Trf, Siderophilin, Serotransferrin, Beta-1 metal-binding globulin, TRF, TF, PRO1400, PRO1557
- Application:
- ELISA
- Buffer:
- Lyophilized from deionized H2O, pH 7-7.5
- CAS Number:
- 11096-37-0
- CE/IVD:
- RUO
- Extra Details:
- Transferrin is a multifunctional monomeric glycoprotein primarily synthesized in the liver and found abundantly in plasma, where it plays a central role in iron metabolism and homeostasis. Each transferrin molecule can reversibly bind two ferric (Fe³⁺) ions with high affinity, facilitating the safe transport and regulated distribution of iron from absorption sites in the gut and macrophages to tissues throughout the body, especially to the bone marrow for hemoglobin synthesis. This iron delivery is mediated through transferrin receptors on cell surfaces, enabling receptor-mediated endocytosis and precise cellular iron uptake. Beyond iron transport, transferrin possesses significant antimicrobial properties by sequestering free iron, thereby limiting its availability to bacteria and fungi-a process that contributes to innate immune defense and exhibits bacteriostatic and fungistatic effects. Clinically, altered transferrin levels are linked to various conditions: increases are seen in iron-deficiency anemia and pregnancy, while decreases occur in inflammatory diseases, nephrotic syndrome, hypoproteinemia, and rare genetic disorders like atransferrinemia, which causes severe anemia and iron overload in tissues. Transferrin's applications extend to clinical diagnostics, where it serves as a biomarker for iron status and certain metabolic disorders, and to biotechnology, where it is an essential supplement in cell culture media for optimal cell growth. Additionally, transferrin and its receptor are being explored as targeted drug delivery vehicles, particularly for crossing the blood-brain barrier and treating central nervous system diseases.
- Formulation:
- Lyophilized from deionized H2O, pH 7-7.5
- Molecular Weight:
- 80 Kda
- Physical State:
- Lyophilized
- Purity:
- ≥98%
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Blue Ice
- Source:
- Source human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Native
