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Assay Kits & ELISAs

arigoPLEX[R] Human CTL/NK activation Multiplex ELISA Kit (IFN gamma, TNF alpha, Perforin, Granzyme B)

Product Sizes
96 wells
ARG83005-96WELLS
Academic Pricing
Please contact us for academic pricing.
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About this Product
SKU:
ARG83005
Additional Names:
IFN gamma: IFNG; Interferon Gamma; Immune Interferon; IFN-Gamma; IMD69; IFG; IFITNF-alpha: TNF; Tumor Necrosis Factor; TNF Alpha; TNFSF2; TNFA; DIF; Tumor Necrosis Factor Ligand Superfamily Membe; TNF-A; Tumor Necrosis Factor (TNF Superfamily, Member 2); Tumor Necrosis Factor Ligand 1F; Tumor Necrosis Factor-Alpha; Tumor Necrotic Factor Alpha; TNF Superfamily, Member 2; TNF, Macrophage-Derived; TNF, Monocyte-Derived; APC1 Protein; Cachectin; TNLG1FPerforin: PRF; Perforin; PFP; P1; HPLH2; Perforin 1 (Pore Forming Protein); Lymphocyte Pore-Forming Protein; Perforin-1; Cytolysin; Perforin 1 (Preforming Protein); PerforinGranzyme B: GZMB; Granzyme B; CTSGL1; CGL1; SECT; HLP; T-Cell Serine Protease 1-3E; Cathepsin G-Like 1; CGL-1; CSP-B; CTLA1; CCPI; CSPB; Granzyme B (Granzyme 2, Cytotoxic T-Lymphocyte-Associated Serine Esterase 1); Cytotoxic T-Lymphocyte Proteinase 2; Cytotoxic Serine Protease B; Human Lymphocyte Protein; Fragmentin 2; EC 3.4.21.79; C11; Cytotoxic T-Lymphocyte-Associated Serine Esterase 1; Lymphocyte Protease; Fragmentin-2; Granzyme 2; Granzyme-2; EC 3.4.21; CTLA-1; GRB
Application:
ELISA
CE/IVD:
RUO
Conjugate:
HRP
Extra Details:
IFN gamma:This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]TNF alpha:This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Aug 2020]Perforin:This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood. [provided by RefSeq, Aug 2017]Granzyme B:This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]
Immunogen:
CTL/NK activation
Physical State:
Cell Culture Supernatant, Plasma, Serum
Reactivities:
Human
References:
The cytotoxicity of γδT cells in non-small cell lung cancer mediated via coordination of the BCL-2 and AKT pathways
Sensitivity:
IFN gamma: 15.625 pg/mlTNF alpha: 23.44 pg/mlPerforin: 93.75 pg/mlGranzyme B: 15.625 pg/ml
Shipping Conditions:
Blue Ice
Storage Conditions:
2-8[o]C, -20[o]C
Supplier:
Arigo Biolaboratories
Type:
Assay Kits: ELISAs
ARG83005 arigoPLEX® Human CTL/NK Activation Multiplex ELISA Kit (IFN gamma, TNF alpha, Perforin, Granzyme B) results of a typical standard for Human Granzyme B run with optical density reading at 450 nm.
ARG83005 arigoPLEX® Human CTL/NK Activation Multiplex ELISA Kit (IFN gamma, TNF alpha, Perforin, Granzyme B) results of a typical standard for Human IFN gamma run with optical density reading at 450 nm.
ARG83005 arigoPLEX® Human CTL/NK Activation Multiplex ELISA Kit (IFN gamma, TNF alpha, Perforin, Granzyme B) results of a typical standard for Human Perforin run with optical density reading at 450 nm.
ARG83005 arigoPLEX® Human CTL/NK Activation Multiplex ELISA Kit (IFN gamma, TNF alpha, Perforin, Granzyme B) results of a typical standard for Human TNF alpha run with optical density reading at 450 nm.
ARG83005 arigoPLEX® Human CTL/NK Activation Multiplex ELISA Kit (IFN gamma, TNF alpha, Perforin, Granzyme B) results of a typical standard for Human TNF alpha run with optical density reading at 450 nm.