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Assay Kits & ELISAs

arigoPLEX[R] Mouse Proinflammatory Cytokine Multiplex ELISA Kit (IFN gamma, IL1 beta, IL6, TNF alpha)

Product Sizes
96 wells
ARG82842-96WELLS
Academic Pricing
Please contact us for academic pricing.
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About this Product
SKU:
ARG82842
Additional Names:
IL1 beta: Interleukin-1 beta; IL1-BETA; IL-1; IL-1 beta; Catabolin; IL1F2IFN gamma: IFN-gamma; Interferon gamma; Immune interferon; IFG; IFITNF alpha: Tumor necrosis factor ligand superfamily member 2; DIF; Cachectin; ICD2; ICD1; N-terminal fragment; TNF-a; TNFA; TNFSF2; TNF-alpha; Tumor necrosis factor; NTFIL6: B-cell stimulatory factor 2; CDF; HSF; BSF-2; Interferon beta-2; IL-6; IFNB2; CTL differentiation factor; Interleukin-6; HGF; Hybridoma growth factor; BSF2; IFN-beta-2
Application:
ELISA
CE/IVD:
RUO
Conjugate:
HRP
Extra Details:
IFN gamma:This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]IL1 beta:The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2020]IL6:This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Aug 2020]TNF alpha:This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Aug 2020]
Immunogen:
ProInflammatory Cytokine
Physical State:
Cell Culture Supernatant, Plasma, Serum
Reactivities:
Mouse
References:
Sustained Exosome-Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins and MiRNAs, and Sustained Release Formulation | Viral Mimetic Bacterial Outer Membrane Vesicles for Targeting Angiotensin-Converting Enzyme 2 | Propagation of senescent phenotypes by extracellular HMGB1 is dependent on its redox state
Sensitivity:
IFN gamma: 31.25 pg/mlIL1 beta: 15.625 pg/mlIL6: 15.625 pg/mlTNF alpha: 31.25 pg/ml
Shipping Conditions:
Blue Ice
Storage Conditions:
2-8[o]C, -20[o]C
Supplier:
Arigo Biolaboratories
Type:
Assay Kits: ELISAs
ARG82842 arigoPLEX® Mouse Proinflammatory Cytokine Multiplex ELISA Kit (IFN gamma, IL1 beta, IL6, TNF alpha) results of a typical standard for Mouse IFN gamma run with optical density reading at 450 nm.
ARG82842 arigoPLEX® Mouse Proinflammatory Cytokine Multiplex ELISA Kit (IFN gamma, IL1 beta, IL6, TNF alpha) results of a typical standard for Mouse IL1 beta run with optical density reading at 450 nm.
ARG82842 arigoPLEX® Mouse Proinflammatory Cytokine Multiplex ELISA Kit (IFN gamma, IL1 beta, IL6, TNF alpha) results of a typical standard for Mouse IL6 run with optical density reading at 450 nm.
ARG82842 arigoPLEX® Mouse Proinflammatory Cytokine Multiplex ELISA Kit (IFN gamma, IL1 beta, IL6, TNF alpha) results of a typical standard for Mouse TNF alpha run with optical density reading at 450 nm.
ARG82842 arigoPLEX® Mouse Proinflammatory Cytokine Multiplex ELISA Kit (IL1 beta, IFN gamma, TNF alpha, IL6) results of a typical standard for Mouse TNF alpha run with optical density reading at 450 nm.