Human ErbB3 / Her3 Protein, Twin-Strep Tag (MALS verified)
Product Sizes
25 ug
ER3-H5288-25UG
250 ug
ER3-H5288-250UG
1 mg
ER3-H5288-1MG
About this Product
- SKU:
- ER3-H5288
- Additional Names:
- c-erbB3|ERBB3|erbB3-S|HER3|LCCS2|MDA-BF-1|MGC88033|p180-ErbB3|p45-sErbB3|p85-sErbB3
- Buffer:
- PBS
- Extra Details:
- ErbB3,also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain. It therefore can bind the ligand but cannot mediate the intracellular signal transduction through protein phosphorylation. However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to give a receptor complex and initiate the related pathway, which lead to cell proliferation or differentiation. Overexpression of this protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.
- Immunogen:
- ErbB3
- Molecular Weight:
- 71.7 kDa
- Physical State:
- Powder
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes
