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Proteins and Peptides

Human Complement C5 (w917s) Protein, His Tag (MALS verified)

Product Sizes
100 ug
CO5-H52H7-100UG
1 mg
CO5-H52H7-1MG
About this Product
SKU:
CO5-H52H7
Additional Names:
C5|Complement C5|CPAMD4
Buffer:
PBS
Extra Details:
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain). Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. The C5a anaphylatoxin interacts with C5AR1 and tick complement inhibitor. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
Immunogen:
Complement C5
Molecular Weight:
73.9 kDa (B Beta chain) & 114.3 kDa (A Alpha chain)
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Human Complement C5 (w917s), His Tag on SDS-PAGE under reducing (R) and under non-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Immobilized Human Complement C5 (w917s), His Tag (Cat. No. CO5-H52H7) at 2 ug/mL (100 uL/well) can bind Monoclonal Anti-Human C5a Human Antibody, Human IgG1 with a linear range of 0.06-2 ng/mL (QC tested).
Immobilized Human Complement C5 (w917s), His Tag (Cat. No. CO5-H52H7) at 2 ug/mL (100 uL/well) can bind Eculizumab Biosimilar with a linear range of 0.2-16 ng/mL (Routinely tested).