MOTS-c
Product Sizes
1 mg
KS-210-1MG
About this Product
- SKU:
- KS-210
- Additional Names:
- Mitochondria-derived peptide MOTS-c, Mitochondrial open reading frame of the 12S rRNA-c|MOTS-c, KS-210, KS210, Mitochondria-derived peptide MOTS-c, MRWQEMGYIFYPRKLR, 627580-64-6, Mitochondrial open reading frame of the 12S rRNA-c
- CAS Number:
- 627580-64-6
- Extra Details:
- MOTS-c is a 16-amino-acid peptide encoded by a short open reading frame (sORF) within the mitochondrial 12S rRNA. MOTS-c, which is a contraction of mitochondrial open reading frame of the 12S rRNA-c, regulates insulin sensitivity and metabolic homeostasis with its primary target organ being skeletal muscle. The cellular action of MOTS-c is to inhibit the folate cycle and its tethered de novo purine biosynthesis, leading to activation of AMP-activated protein kinase (AMPK), a central regulator of energy homeostasis. In mouse models, MOTS-c treatment prevents age dependent and high fat diet-induced insulin resistance, as well as diet induced obesity.
- Immunogen:
- Kinases
- Molecular Weight:
- 2174.62
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Lee et al (2015) The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. <strong>21</strong>(3) 443Â <a href="https://pubmed.ncbi.nlm.nih.gov/25738459/" target="_blank" rel="nofollow">PMID: 25738459</a></p><p>Wei et al (2020) Mitochondrial-Derived Peptide MOTS-c Attenuates Vascular Calcification and Secondary Myocardial Remodeling via Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway. Cardiorenal Med. <strong>10</strong>(1) 42Â <a href="https://pubmed.ncbi.nlm.nih.gov/31694019/" target="_blank" rel="nofollow">PMID: 31694019</a></p><p>Reynolds et al (2021) MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. <strong>12</strong>(1) 470Â <a href="https://pubmed.ncbi.nlm.nih.gov/33473109/" target="_blank" rel="nofollow">PMID: 33473109</a></p><hr id="null">
- Sequence:
- H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C101H152N28O22S2
