st-Ht31
About this Product
- SKU:
- KS-200
- Additional Names:
- S-Ht31, st-Ht 31 (493-515)|st-Ht31, KS-200, KS 200, KS200, 188425-80-1, Stearyl-DLIEEAASRIVDAVIEQVKAAGAY, DLIEEAASRIVDAVIEQVKAAGAY , S-Ht31
- CAS Number:
- 188425-80-1
- Extra Details:
- st-Ht31 is a stearated and cell permeable version of the peptide Ht-31, which inhibits the interaction between the RII subunits of cAMP-dependent PKA and A-kinase anchoring protein (AKAP). The sequence of st-Ht31 is derived from human thyroid RII anchoring protein Ht31, comprising residues 493-515, and is the minimum region of Ht 31 required for RII binding. Disruption of the AKAP-PKA interaction by st-Ht31 alters human airway smooth muscle proliferation and enhances contractile force generation with upregulation of the contractile protein A Alpha-sm-actin. st-Ht31 also increases cytosolic PKA activity and is able to reverse foam cell formation and restore metabolic health in otherwise dysfunctional macrophages.
- Immunogen:
- Protein-protein interactions,Kinases
- Molecular Weight:
- 2798.27
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Carr (1992) Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain. J Biol Chem. <strong>267</strong>(19) 13376 <a href="https://pubmed.ncbi.nlm.nih.gov/1618839/" target="_blank" rel="nofollow">PMID: 1618839</a></p><p>Ma et al (2011) Ht31, a protein kinase A anchoring inhibitor, induces robust cholesterol efflux and reverses macrophage foam cell formation through ATP-binding cassette transporter A1. J Biol Chem.<strong> 286</strong>(5) 3370 <a href="https://pubmed.ncbi.nlm.nih.gov/21106522/" target="_blank" rel="nofollow">PMID: 21106522</a></p><p>Baarsma et al (2020) Disruption of AKAP-PKA Interaction Induces Hypercontractility With Concomitant Increase in Proliferation Markers in Human Airway Smooth Muscle. Front Cell Dev Biol. <strong>8</strong> 165 <a href="https://pubmed.ncbi.nlm.nih.gov/32328490/" target="_blank" rel="nofollow">PMID: 32328490</a><br></p>
- Sequence:
- Stearyl-Asp-Leu-Ile-Glu-Glu-Ala-Ala-Ser-Arg-Ile-Val-Asp-Ala-Val-Ile-Glu-Gln-Val-Lys-Ala-Ala-Gly-Ala-Tyr-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in 0.01M PBS
- Formula:
- C129H217N29O39
