MECT1 Antibody
Product Sizes
100 ug
600-401-936-100UG
About this Product
- SKU:
- 600-401-936
- Additional Names:
- CRTC1|rabbit anti-MECT1 antibody, MECT-1, MECT 1, TORC1, TORC-1, TORC 1, WAMTP1, WAMTP-1, CRTC1, CRTC-1, CREB-regulated transcription coactivator 1, Mucoepidermoid carcinoma translocated protein 1, Transducer of regulated cAMP response element-binding protein 1, Transducer of CREB protein 1
- Application:
- ChIP, ELISA, Immunohistochemistry, Western Blot
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- CE/IVD:
- RUO
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This antibody is designed, produced, and validated as part of a collaboration between Rockland and the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. MECT1 (also known as Mucoepidermoid Carcinoma Translocated 1) is a nuclear protein that functions as a transcriptional coactivator for CREB1, which activates transcription through both consensus and variant cAMP response element (CRE) sites. It acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 Ser-133 phosphorylation. MECT1 enhances the interaction of CREB1 with TAF4. It regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Mect1 is a potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. MECT1 is also a coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, it is involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. MECT1 may be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, MECT1 regulates the light-induced entrainment of the circadian clock. In response to light stimulus, it coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. Therefore, it has been found to be important for energy balance and reproduction. Anti-MECT1 (CRTC1) Antibody is useful for researchers interested in glucose energy metabolism, circadian rhythms, and hormone research.
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Host:
- Rabbit
- Immunogen:
- This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 19-34 of human MECT1 protein.
- Isotype:
- IgG
- Physical State:
- Liquid
- Reactivities:
- Bovine, Fish, Human, Mouse, Rat
- Shipping Conditions:
- Dry Ice
- Specificity:
- This affinity-purified antibody is directed against human MECT1 protein. The product was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross reactivity with MECT1 protein from human, mouse, rat, zebrafish, pufferfish and bovine based on 100% homology with the immunizing sequence. Reactivity against homologues from other sources i
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:https://www.rockland.com/search/?searchString=600-401-936
