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NCC Antibody: ATTO 594

SKU:
SPC-402D-A594
Additional Names:
SLC12A3 Antibody, SCYL1 Antibody,CKb10 Antibody, MCP-4 Antibody, MGC17134 Antibody, NCC-1 Antibody, NCC1 Antibody, SCYA13 Antibody, CK-beta-10 Antibody, monocyte chemoattractant protein 4 Antibody, monocyte chemotactic protein 4 Antibody, new CC chemokine 1 Antibody, small inducible cytokine A13 Antibody, small inducible cytokine subfamily A (Cys-Cys) member 13 Antibody, chemokine (C-C) Antibody
Application:
Electron Microscopy, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
CE/IVD:
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Clonality:
Polyclonal
Conjugate:
ATTO 594
Concentration:
1 mg/ml
Extra Details:
NCC, a thiazide-sensitive NaCl co-transporter, is found on the apical membrane of the distal convoluted tubule, where it is the principal mediator of Na+ and Cl- reabsorption in this segment of the nephron. It is activated by phosphorylation, and has been implicated in renal NaCl and K+ homeostasis (1). Regulation of NCC expression and phosphorylation by dietary NACl restriction appears to involve SGK1(1). In experiments with angiotensin II-infused mice, increased sensitivity to Ang II may involved over-activity of NCC (2). Therefore, NCC is the target of thiazide diuretics used in the treatment of hypertension (1). Molecular experiments have also shown that NCC has been detected in the lens cortex, core and fiber cells of a rat (3).
Gene Details:
Slc12a3, SLC12A3
Host:
Rabbit
Immunogen:
Produced against a synthetic peptide mapping to a segment of rat NCC (amino acids 74-95), N-terminal
Protein Details:
P55017, P55018
Purification:
Affinity Purified
Reactivities:
Canine, Human, Mouse, Rat
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C
Supplier:
StressMarq Biosciences
Type:
Antibody: Polyclonal Antibody
Size:
100 ug
Specificity:
Detects ~160kDa.
Preservative:
0.09% Sodium azide
Long Description:
Rabbit Anti-Rat NCC Polyclonal
Accession:
NP_000330, NP_062218
Synonyms:
Na-Cl cotransporter;NaCl electroneutral thiazide-sensitive cotransporter;Na-Cl symporter;NCC;NCCT;solute carrier family 12 (sodium/chloride transporter), member 3;solute carrier family 12 (sodium/chloride transporters), member 3;solute carrier family 12 member 3;thiazide-sensitive Na-Cl cotransporter;thiazide-sensitive sodium-chloride cotransporter;TSC
Price for 100 ug £469.00

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