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Learn more about the roles of HMGB1 and how Arigo Biolaboratories can aid your research.

HMGB1 is a multifunctional protein with various roles in different cellular compartments. It is associated with various pathogenesis such as cancers, neurodegenerative disorders, and multiple inflammatory diseases. As it is a therapeutic target for a wide range of diseases, this protein has received high interest from many researchers.

Roles of the HMGB1 protein

In the nucleus - HMGB1 acts as a DNA-binding protein for:

  • Gene Transcription
  • Gene Regulation
  • DNA repair

In the cytosol, HMGB1 induces autophagy by interacting with Beclin-1 which results in its dissociation from Bcl2 and the subsequent induction of autophagy.

Arigo's related HMGB1 products:

Stimulation:HMGB1 protein (ARG70220)
Neutralization:HMGB1 Neutralizing antibody
[SQab20175] (ARG66714)
Detection:HMGB1 antibody [SQab1711] (ARG65863)
Quantification:Human HMGB1 ELISA Kit (ARG81185)
Mouse/Rat HMGB1 ELISA Kit (ARG81310)
Serum HMGB1 ELISA Kit (ARG81351)

Take a look at the diagram below to see many of the interactions of HMGB1 in various biological processes.