Transthyretin Y78F Variant Filaments
Product Sizes
100 ug
SPR-465-100UG
2 x 100 ug
SPR-465-2X100UG
5 x 100 ug
SPR-465-5X100UG
About this Product
- SKU:
- SPR-465
- Additional Names:
- Transthyretin Y78F, TTR Y78F, ATTR, Amyloid polyneuropathy, Amyloidosis I, Carpal tunnel syndrome 1, CTS, CTS1, HEL111, HsT2651, PALB, Prealbumin, Prealbumin amyloidosis type I, Prealbumin Thyroxine-binding, TBPA, Thyroxine binding prealbumin, TTHY_HUMAN, TTR
- Application:
- Cell-based/Functional Assay, SDS-PAGE, Western Blot
- Buffer:
- PBS
- CE/IVD:
- RUO
- Extra Details:
- Transthyretin (TTR), encoded by the TTR gene (UniProt ID: P02766), is a tetrameric transport protein primarily responsible for carrying thyroxine and retinol-binding protein in plasma and cerebrospinal fluid. Under pathological conditions, TTR can misfold and aggregate into amyloid fibrils, contributing to systemic and neurological disorders. The Y78F mutation involves a substitution of tyrosine with phenylalanine at position 78, a site critical for TTR's structural stability and interaction with ligands. This variant alters the protein's folding dynamics, increasing its propensity to dissociate into monomers and form amyloid filaments. These filaments exhibit enhanced stability and aggregation potential, making them a valuable model for studying the molecular mechanisms underlying transthyretin amyloidosis and its neurological manifestations. TTR Y78F filaments are used in experimental systems to investigate protein misfolding, cellular toxicity, and tissue-specific deposition. Their structural fidelity to patient-derived amyloid aggregates enables high-resolution studies of neurodegenerative processes, including oxidative stress, inflammation, and neuronal dysfunction. These filaments also support therapeutic development by providing a consistent platform for screening stabilizers, aggregation inhibitors, and clearance-enhancing agents. As a result, TTR Y78F variant filaments are instrumental in advancing translational research focused on amyloid-related neurodegenerative diseases.
- Immunogen:
- Transthyretin (TTR) Y78F Filaments
- Molecular Weight:
- 13.876 kDa
- Purity:
- >95%
- Purification:
- Ion Exchange
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/protein/ttr-protein-spr-465/
