Transthyretin L55P Variant Filaments
Product Sizes
100 ug
SPR-464-100UG
2 x 100 ug
SPR-464-2X100UG
5 x 100 ug
SPR-464-5X100UG
About this Product
- SKU:
- SPR-464
- Additional Names:
- Transthyretin L55P, TTR L55P, ATTR, Amyloid polyneuropathy, Amyloidosis I, Carpal tunnel syndrome 1, CTS, CTS1, HEL111, HsT2651, PALB, Prealbumin, Prealbumin amyloidosis type I, Prealbumin Thyroxine-binding, TBPA, Thyroxine binding prealbumin, TTHY_HUMAN, TTR
- Application:
- Cell-based/Functional Assay, SDS-PAGE, Western Blot
- Buffer:
- PBS
- CE/IVD:
- RUO
- Extra Details:
- Transthyretin (TTR), encoded by the TTR gene (UniProt ID: P02766), is a tetrameric transport protein primarily responsible for carrying thyroxine and retinol-binding protein in the bloodstream. Under pathological conditions, TTR can misfold and aggregate into amyloid fibrils, contributing to systemic and neurological disorders. The L55P mutation in TTR significantly destabilizes its native tetrameric structure, promoting dissociation into monomers that readily misassemble into amyloid filaments. These filaments are implicated in hereditary transthyretin amyloidosis (ATTRv), a progressive condition marked by polyneuropathy, autonomic dysfunction, and organ impairment. The L55P variant is among the most amyloidogenic mutations, producing highly stable and neurotoxic fibrils that closely resemble those found in patient tissues. TTR L55P filaments serve as a powerful model for studying the molecular basis of amyloid formation, neurotoxicity, and tissue-specific deposition. Their use in experimental systems enables detailed investigation of protein misfolding pathways, cellular stress responses, and neurodegenerative mechanisms. These filaments also facilitate the development and screening of therapeutic agents aimed at stabilizing native TTR, inhibiting fibril formation, or enhancing amyloid clearance. By replicating key features of human amyloid pathology, TTR L55P variant filaments are essential tools in translational research targeting neurodegenerative diseases associated with protein aggregation.
- Immunogen:
- Transthyretin (TTR) L55P Filaments
- Molecular Weight:
- 13.876 kDa
- Purity:
- >95%
- Purification:
- Ion Exchange
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/protein/ttr-protein-spr-464/
