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Antibodies

Collagen Type III Antibody Peroxidase Conjugated

Product Sizes
50 ug
600-403-105-50UG
About this Product
SKU:
600-403-105
Additional Names:
COL3A1|rabbit anti-Collagen Type III antibody peroxidase conjugation, HRP conjugated rabbit anti-Collagen Type III antibody, Collagen type III alpha 1 antibody, Collagen type III alpha antibody, EDS4A antibody, Ehlers Danlos syndrome type IV, autosomal dominant antibody, Fetal collagen antibody, COL3A1, Collagen alpha-1 (III) chain
Application:
ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
Buffer:
0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
CE/IVD:
RUO
Clonality:
Polyclonal
Conjugate:
HRP
Concentration:
1 mg/ml
Extra Details:
In muscle tissue, collagen serves as a major component of the endomysium. Collagen constitutes one to two percent of muscle tissue, and accounts for 6% of the weight of strong, tendinous muscles. A collagen may be defined as a protein containing sizable domain(s) of triple-helical conformation. Type IV collagen is a major macromolecular constituent of basement membranes and can be readily isolated from basement-membrane-rich tissues or highly vascularized tissues such as the placental villi. This collagen appears to be largely restricted to structures identifiable as basement membranes. In contrast, type VI collagen appears to be prevalent in several tissues even though it has been isolated largely from placental villi preparations. The extent to which type VII and VIII collagens are distributed is not known.
Formulation:
0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
Host:
Rabbit
Immunogen:
Collagen Type III from human and bovine placenta
Isotype:
IgG
Physical State:
Lyophilized
Reactivities:
Bovine, Human
Shipping Conditions:
Ambient
Specificity:
This product has been prepared by immunoaffinity chromatography using immobilized antigens. Some class-specific anti-collagens may be specific for three-dimensional epitopes which may result in diminished reactivity with denatured collagen or formalin-fixed, paraffin embedded tissues. This antibody reacts with most mammalian Type III collagens and has expected cross-reactivity with Type I and negl
Storage Conditions:
2-8[o]C liquid. Aliquot. Avoid freeze/thaw cycles.
Supplier:
Rockland Inc
Type:
Antibody: Polyclonal Antibody
Immunohistochemistry of Anti-Collagen Type III Peroxidase Conjugated. WT mice have significantly increased collagen type I expression in the tendon adhesions. Representative images of collagen type I expression (gold) in the tendon adhesions of WT (a-b) and FliiTg/Tg (e-f) mice and collagen type III expression (gold) in the tendon adhesions of WT (c-d) FliiTg/Tg (g-h) at 21 and 28 days post 50% partial laceration injury. (i) WT mice have significantly upregulated collagen type I levels in the adhesions compared with FliiTg/Tg mice. (j) No significant difference was noted in collagen type III levels in WT and FliiTg/Tg mice, although detectable levels of collagen type III were found in the FliiTg/Tg mice. DAPI is represented as blue fluorescence; t, tendon; d, dermis. Dotted line represents tendon adhesion area. Magnification x 10. Scale bar = 200 uM and refers to all images. Data represented as mean +/- SEM. *p ≤ 0.05. n = 6. Fig. 7. PMID: 32854733.