TNFSF1A
Product Sizes
100 ug
£674.12
103-M493-100UG
About this Product
- SKU:
- 103-M493
- Additional Names:
- Tnf; DIF; Tnfa; TNFSF2; Tnfsf1a; TNFalpha; TNF-alpha
- Application:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 7F34
- Clonality:
- Monoclonal
- Extra Details:
- Tumor necrosis factor alpha (TNF-A Alpha), also known as cachectin and TNFSF1A, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNF-A Alpha is produced by a wide variety of immune and epithelial cell types. Human TNF-A Alpha consists of a 35 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 177 aa extracellular domain (ECD). Within the ECD, human TNF-A Alpha shares 97% aa sequence identity with rhesus and 71% - 92% with bovine, canine, cotton rat, equine, feline, mouse, porcine, and rat TNF-A Alpha. The 26 kDa type 2 transmembrane protein is assembled intracellularly to form a noncovalently linked homotrimer. Ligation of this complex induces reverse signaling that promotes lymphocyte costimulation but diminishes monocyte responsiveness.
- Formulation:
- lyophilized
- Host:
- Rat
- Immunogen:
- Mouse recombinant protein TNFSF1A
- Isotype:
- IgG2
- Purification:
- Protein A/G Purified
- Reactivities:
- Mouse
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody