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Antibodies

P-Selectin

Product Sizes
100 ug
£674.12
103-M457-100UG
About this Product
SKU:
103-M457
Additional Names:
Selp; Grmp; CD62P; LECAM3; PADGEM; GMP-140
Application:
Western Blot
Buffer:
PBS
translate.label.attr.clone:
17H23
Clonality:
Monoclonal
Extra Details:
Mouse -P-Selectin (GMP140, LECAM3, PADGEM, CD62P), a member of the Selectin family, is a cell surface glycoprotein expressed by activated platelets and endothelial cells. P- Selectin is translocated to the cell surface within minutes, from alpha granules of platelets or WeibelPalade bodies of endothelial cells, following stimulation with thrombin, histamine, PMA or peroxides. P-Selectin binds to a 106 kDa protein present on myeloid cells, neutrophils, monocytes and lymphocytes, termed PSGL 1 (PSelectin glycoprotein ligand1). PSelectin plays a role in the adhesion of leukocytes and neutrophils to the endothelium. Acting in cooperation with LSelectin, PSelectin mediates the initial interaction of circulating leukocytes with endothelial cells that produces a characteristic 'rolling' of the leukocytes on the endothelium. This initial interaction is followed by a stronger interaction involving ESelectin, and later ICAM1 and VCAM1, that leads eventually to extravasation of the white blood cell through the blood vessel wall into the extracellular matrix tissue. Mouse P-Selectin cDNA encodes a 768 amino acid (aa) residue type I transmembrane protein with a 41 aa signal peptide, a 668 aa extracellular domain, a transmembrane domain and a short (35 aa) cytoplasmic domain. The extracellular domain has an NH2t-erminal C-type lectin domain and an EGF like domain followedby a series of of complement factor A repeat homology domains. The extracellular domains of human and mouse P-Selectin share approximately 73% sequence homology.
Formulation:
lyophilized
Host:
Rat
Immunogen:
recombinant mouse P-Selectin extracellular domain
Isotype:
IgG2
Purification:
Protein G Purified
Reactivities:
Mouse
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody