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Antibodies

Oncostatin M

Product Sizes
100 ug
£674.12
103-M446-100UG
About this Product
SKU:
103-M446
Additional Names:
OSM
Application:
Western Blot
Buffer:
PBS
translate.label.attr.clone:
7H61
Clonality:
Monoclonal
Extra Details:
Oncostatin M (OSM) is a member of the IL-6 family of cytokines that is produced primarily by activated T cells and macrophages. OSM induces fibroblast proliferation, inhibits tumor cell proliferation, and plays a role in immune regulation. Mouse OSM binds to the OSM receptor B Beta (OSMRB Beta) which forms a heteromeric complex with the common IL-6 family receptor subunit, gp130. In contrast, human OSM binds to two distinct receptor complexes, the OSMRB Beta/gp130 and LIFRB Beta/gp130 complexes. The ability of human OSM to bind to two receptors may explain the overlapping and distinct activities of human OSM and LIF. OSM induces the activation the JAK2, STAT3, and ERK1/2 pathways.
Formulation:
lyophilized
Host:
Rat
Immunogen:
recombinant mouse Oncostatin
Isotype:
IgG2
Purification:
Protein G Purified
Reactivities:
Mouse
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody