Dectin-2
Product Sizes
100 ug
£674.12
103-M371-100UG
About this Product
- SKU:
- 103-M371
- Additional Names:
- Clec4n; Nkcl; Clec6a; Clecsf10
- Application:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 7B45
- Clonality:
- Monoclonal
- Extra Details:
- Dectin2A Alpha or Dectin2, also known as CLEC6A, CLECSF10, and NKCL, belongs to the Ctype lectin family of transmembrane immune regulatory glycoproteins. Dectin 2A Alpha, CLEC4A/DCIR, CLEC4B/DCAR, CLEC4C/DLEC, CLEC4D/MCL, and CLEC4E/mincle constitute a subgroup of these molecules that exhibit approximately 40% amino acid (aa) sequence identity in their extracellular domains (ECD) and have a conserved cysteine spacing in their carbohydrate recognition domains (CRD). Mature mouse Dectin2A Alpha consists of a short cytoplasmic tail, a transmembrane segment, and an ECD with a stalk region and one CRD. Alternate splicing leads to partial deletion of the transmembrane segment and stalk ( B Beta isoform) or a portion of the CRD (G Gamma isoform). The full length Dectin2A Alpha isoform is a 27 kDa molecule that is primarily expressed on the surface of tissue macrophages and their precursors. The CRD of Dectin2A Alpha contains an EPN motif which is characteristic of calciumdependent mannosebinding lectins. Dectin2A Alpha selectively interacts with high mannose structures in the Man9GlcNAc2 configuration. It mediates the recognition of a variety of microorganisms, particularly the filamentous forms of yeast and fungii. The short cytoplasmic tail does not contain signaling motifs but mediates association with the ITAMcontaining Fc receptor G Gamma subunit in macrophages. Ligation of Dectin2A Alpha induces tyrosine phosphorylation of the G Gamma subunit, activation of NFK KappaB, and enhanced release of TNFA Alpha and IL1ra. Macrophage Dectin2A Alpha is upregulated in vivo by inflammatory stimuli and UVB irradiation. It mediates the breaking of UVinduced tolerance by interacting with CD4+CD25+ regulatory T cells which then induce dendritic cells to release IL4, IL10, and TGFB Beta. Within the ECD, mouse Dectin2A Alpha shares 71% aa sequence identity with human and bovine Dectin2.
- Formulation:
- lyophilized
- Host:
- Rat
- Immunogen:
- Mouse recombinant protein Dectin-2
- Isotype:
- IgG2
- Purification:
- Protein G/A chromatography
- Reactivities:
- Mouse
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody