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Antibodies

Dtk

Product Sizes
100 ug
£674.12
103-M186-100UG
About this Product
SKU:
103-M186
Additional Names:
Tyro3; Brt; Dtk; Rse; Sky; Tif; Etk-2; AI323366
Application:
IHC-Paraffin, Western Blot
Buffer:
PBS
translate.label.attr.clone:
9J17
Clonality:
Monoclonal
Extra Details:
Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken cEyk) constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. All three receptors bind the vitamin K-dependent protein growth-arrest specific gene 6 (Gas6) which is structurally related to the anti-coagulation factor protein S. The binding affinities for Gas6 is in the order of Axl > Dtk > Mer. Gas6 binding induces tyrosine phosphorylation and downstream signaling pathways that can lead to cell proliferation, migration, or the prevention of apoptosis. Dtk is widely expressed during embryonic development. In adults, Dtk is predominantly expressed in neurons in restricted regions of the brain.
Formulation:
lyophilized
Host:
Rat
Immunogen:
recombinant mouse Dtk extracellular domain
Isotype:
IgG1
Purification:
Protein G Purified
Reactivities:
Mouse
Shipping Conditions:
Ambient
Storage Conditions:
-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody