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Antibodies

Trophoblast glycoprotein (5T4)

Product Sizes
100 ug
£674.12
101-M853-100UG
About this Product
SKU:
101-M853
Additional Names:
5T4 oncofetal trophoblast glycoprotein, 5T4, 5T4-AG, 5T4M6P1,5T4 oncofetal antigen, TPBG, trophoblast glycoprotein
Application:
Flow Cytometry, Immunohistochemistry
Buffer:
PBS
translate.label.attr.clone:
7A11
Clonality:
Monoclonal
Extra Details:
Trophoblast glycoprotein, also known as TPBG, 5T4, Wnt-Activated Inhibitory Factor 1 or WAIF1, is a human protein encoded by a TPBG gene.[5] TPBG is an antagonist of Wnt/B Beta-catenin signalling pathway. 5T4 is an antigen expressed in a number of carcinomas. It is an N-glycosylated transmembrane 72 kDa glycoprotein containing eight leucine-rich repeats. 5T4 is often referred to as an oncofetal antigen due to its expression in foetal trophoblast (where it was first discovered) or trophoblast glycoprotein (TPBG). 5T4 is found in tumors including the colorectal, ovarian, and gastric. Its expression is used as a prognostic aid in these cases. It has very limited expression in normal tissue but is widespread in malignant tumours throughout their development. One study found that 5T4 was present in 85% of a cohort of 72 colorectal carcinomas and in 81% of a cohort of 27 gastric carcinomas.
Formulation:
lyophilized
Host:
Mouse
Immunogen:
Recombinant human 5T4
Isotype:
IgG1
Purification:
Protein G Purified
Reactivities:
Human
Shipping Conditions:
Ambient
Storage Conditions:
-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody