IL-13 receptor alpha 2
Product Sizes
100 ug
£674.12
101-M479-100UG
About this Product
- SKU:
- 101-M479
- Additional Names:
- IL13RA2; CT19; IL-13R; IL13BP; CD213A2
- Application:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 11S23
- Clonality:
- Monoclonal
- Extra Details:
- Two members of the type 5 subfamily of type I cytokine receptors can serve as receptors for IL-13. IL-13 can bind to IL-13 R alpha 1 (CD213a1; previously designated IL-13 R alpha or NR4) with low affinity, then recruits the IL-4 R alpha chain to form a high affinity receptor, causing downstream STAT6 activation. Alternately, IL-13 can bind IL-13 R alpha 2 (CD213a2) with high affinity; this interaction does not cause activation of STAT6, but does induce TGF-beta production. IL-13 R alpha 1 and IL-13 R alpha 2 each have three extracellular fibronectin type III domains, two cytokine receptor homology modules and a WSXWS motif typical of the class I cytokine receptor family, but IL-13 R alpha 2 has a much shorter cytoplasmic tail. IL-13 R subunits can be expressed on monocytes, macrophages, fibroblasts, human B cells, basophils, eosinophils, endothelial cells, and smooth muscle cells.
- Formulation:
- lyophilized
- Host:
- Mouse
- Immunogen:
- recombinant human IL-13R alpha 2 EC domain
- Isotype:
- IgG1
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody