anti-Synaptopodin N-terminus, guinea pig polyclonal antibody
Product Sizes
100 ul
£394.00
GP94-N-100UL
About this Product
- SKU:
- GP94-N
- Additional Names:
- Synaptopodin, SYNPO, KIAA1029
- Application:
- Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
- CE/IVD:
- RUO
- Clonality:
- Polyclonal
- Extra Details:
- The antibody reacts specifically with the N-terminus of synaptopodin/SYNPO, a prolin-rich actin-binding protein with 2 binding sites for actin. Synaptopodin belongs to actin-binding pro-teins, it has first been localized in podocytes and a subset of telencephalic postsynaptic densities. In human tissue synaptopodin has a molecular weight of 73.7 kD and pI of 9.38 (calculated from sequence data); in mouse the corre-sponding data are 74 kD, pI 9.27. In SDS-PAGE the antigen appears as 100 kD polypeptide in brain and 110 kD polypeptide in kidney (attributed to posttransla-tional modifications). In Western blot analysis the antibody also reacts with a 44 kD degradation fragment of synaptopodin. The antibody recognizes differentiated podocytes (glomerular visceral epithelial cells) in vivo and in vitro (weaker additional reaction with arterial endothelial cells), co-localization with alpha-actinin. Reacts with a subset of exclusively telencephalic synapses. Differentiation-dependent expression during postnatal maturation of murine brain. Differentiation-dependent expression in cultured hippocampal neurons.
- Formulation:
- Contains 0.09% sodium azide and 0.5% BSA
- Host:
- Guinea Pig
- Immunogen:
- Synthetic peptides (mouse N-terminus), coupled to KLH
- Purification:
- Stabilized antiserum
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Progen
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:GP94-N
