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Antibodies

anti-p100 Nuclear Coactivator, guinea pig polyclonal antibody

Product Sizes
100 ul
£334.00
GP25-100UL
About this Product
SKU:
GP25
Application:
Immunohistochemistry, Western Blot
CE/IVD:
RUO
Clonality:
Polyclonal
Extra Details:
p100 is a ubiquitously expressed protein highly conserved during evolution, enhancing e.g. transciptional activity of EBNA2 of EBV, bridging STAT6 with the basal transcription machinery, also described as a part of the RNA polymerase II holoenzyme (Yang et al.). The antiserum localized p100 also in the ER and lipid droplets of milk secreting cells. In addition to the nuclear localization the protein was also detected in cytosolic fractions from lactating mammary gland, in storage lipid droplets from adipocytes and in ER from liver (Keenan et al.). Reactivity on cultured cell lines: BMGE (bovine mammary epithelial cells). Yang J, Aittomaki S, Pesu M, Carter K, Saarinen J, Kalkkinnen N, Kieff E, Silvennoinen O: Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II. EMBO J 21, 4950-4958 (2002). Keenan TW, Winter S, Rackwitz HR, Heid HW: Nuclear coactivator protein p100 is present in endoplasmic reticulum and lipid droplets of milk secreting cells. Biochim Biophys Acta 1523, 84-90 (2000).
Formulation:
Contains 0.09% sodium azide and 0.5% BSA
Host:
Guinea Pig
Immunogen:
Synthetic duplicated C-terminus of human p100 protein conjugated to KLH
Purification:
Stabilized antiserum
Reactivities:
Bovine, Human, Insect/Arthropod, Mouse, Rat
Shipping Conditions:
Blue Ice
Storage Conditions:
Please refer to datasheet
Supplier:
Progen
Type:
Antibody: Polyclonal Antibody
  • Manufacturer's Data Sheet:GP25