anti-LDL Receptor, IgG-C7, mouse monoclonal antibody
Product Sizes
50 ug
£315.00
61087-50UG
About this Product
- SKU:
- 61087
- Additional Names:
- Low-density lipoprotein receptor, LDL receptor, LDLR
- Application:
- Immunocytochemistry, Immunofluorescence
- CE/IVD:
- RUO
- translate.label.attr.clone:
- IgG-C7
- Clonality:
- Monoclonal
- Concentration:
- 50 ug/ml
- Extra Details:
- Suitable for analysis of LDL receptor function in patients with familial hypercholesterolemia. The antibody recognizes an epitope in the region of repeat #1 of the ligand binding region. Addition of 15 nM antibody results in inhibition of half-maximal LDL-binding (Beisiegel et al. 1981). In human normal fibroblasts the antibody detects the 160 kDa polypeptide (pI 4.3) and also in bovine adrenal gland (160 kDa; pI 4.6) of LDL receptors (Beisiegel et al. 1982). Beisiegelt, U., Schneider, W. J., Brown, M. S. & Goldstein, J. L. Immunoblot Analysis of Low Density Lipoprotein Receptors in Fibroblasts from Subjects with Familial Hypercholesterolemia. J. Biol. Chem. 257, 13150-13156 (1982). Beisiegel, U., Schneider, W. J., Goldstein, J. L., Anderson, R. G. & Brown, M. S. Monoclonal antibodies to the low density lipoprotein receptor as probes for study of receptor-mediated endocytosis and the genetics of familial hypercholesterolemia. J. Biol. Chem. 256, 11923-31 (1981).
- Formulation:
- Lyophilized; reconstitute in 1 ml dist. water (final solution contains 0.5% BSA in PBS buffer, pH 7.4)
- Host:
- Mouse
- Immunogen:
- Purified bovine adrenal cortex LDL receptor
- Isotype:
- IgG2b, kappa
- Physical State:
- Lyophilized
- Purification:
- Affinity Purified
- Reactivities:
- Bovine, Canine, Hamster, Human, Mouse, Rabbit, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C reconstituted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Progen
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:61087