PI(3 4)P2 diC8
Product Sizes
100 ug
ECH-P-3408-100UG
500 ug
ECH-P-3408-500UG
1 mg
ECH-P-3408-1MG
About this Product
- SKU:
- ECH-P-3408
- Extra Details:
- PI(3 4)P2 diC8 (Phosphatidylinositol 3 4-bisphosphate diC8) is a synthetic purified dioctanoyl PI(3 4)P2.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3 4-bisphosphate (PI(3 4)P2) is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP TPTE etc.). PI(3 4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions.Product Keywords: Dioctanoyl Phosphatidylinositol 3 4-bisphosphate PtdIns(3 4)P2 C8 PI(3 4)P2 C8 or PI34P2.Bulk discounts available please email echelon@echelon-inc.com for details.Publication Powered by Bioz See more details on Bioz1. Elge S. C. Brearley et al. (2001). "An Arabidopsis inositol phospholipid kinase strongly expressed in procambial cells: synthesis of PtdIns(4 5)P2 and PtdIns(3 4 5)P3 in insect cells by 5-phosphorylation of precursors." Plant J 26(6): 561-71.2. Tong Q. N. Gamper et al. (2004). "Direct activation of the epithelial Na(+) channel by phosphatidylinositol 3 4 5-trisphosphate and phosphatidylinositol 3 4-bisphosphate produced by phosphoinositide 3-OH kinase." J Biol Chem 279(21): 22654-63.3. Shen J. et al. (2009). "Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis." Nat Cell Biol 11(6): 769-776.4. Lopez S. M. et al. (2013). "Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities." Biochem Biophys Res Commun 440(2): 277-282.5. Choi S. et al. (2019). "A nuclear phosphoinositide kinase complex regulates p53." Nature cell biology 21: 462-475.
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
