Often, we suggest Absolute Antibody to researchers requiring an antibody clone which has a different species, isotype or subtype to the original product. For example, in a situation where the existing hybridoma produces a rat or rabbit antibody yet our customer wishes to perform a long-term treatment in mouse, Absolute Antibody can easily switch the antibody species to mouse to reduce immunogenicity. We have also recently recommended Absolute Antibody to researchers wishing to change the effector function of an antibody to enhance ADCC, and to customers wanting to convert an existing antibody to a fragment to block a receptor without incurring Fc-mediated effects. In addition, we regularly propose Absolute Antibody as a reliable source of higher purity antibodies and antibodies that demonstrate lower endotoxin levels.
Recombinant Anti-CD8 antibody maintains T-cell depletion for over 60 days when reformatted as a mouse IgG2a, whereas the original rat IgG2b format loses efficacy after two weeks.