NaVbeta3 Antibody, Clone N396/29: Biotin
Product Sizes
100 ug
SMC-490D-BI-100UG
About this Product
- SKU:
- SMC-490D-BI
- Additional Names:
- Sodium channel subunit beta-3 Antibody, Scn3b Antibody, KIAA1158 Antibody
- Application:
- Immunocytochemistry, Immunofluorescence, Western Blot
- Buffer:
- PBS
- CE/IVD:
- RUO
- translate.label.attr.clone:
- N396/29 (Formerly sold as S396-29)
- Clonality:
- Monoclonal
- Conjugate:
- Biotin
- Concentration:
- 1 mg/ml
- Extra Details:
- Nav Beta 3 (SCN3B) belongs to the voltage-gated sodium channel group, and modulates channel gating kinetics. It inactivates the sodium channel opening more slowly than its Beta1 subunit. It is also unique in causing persistent sodium currents which are thought to amplify summation of synaptic imputs which is likely to increase the excitability of specific neurons to their individual inputs (2). Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (1, 2). Defects in SCN3B are the cause of Brugada syndrome (3).
- Host:
- Mouse
- Immunogen:
- Fusion protein amino acids 1-215 (full-length) of rat NavBeta3
- Isotype:
- IgG2b
- Purification:
- Protein G Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Specificity:
- Detects ~40kDa. Does not cross-reat with NavBeta1, Navbeta2, or Navbeta4.
- Storage Conditions:
- See Manual
- Supplier:
- StressMarq Biosciences
- Type:
- Antibody: Monoclonal Antibody
