Hemoglobin beta F Antibody
Product Sizes
100 ug
200-301-GS6-100UG
About this Product
- SKU:
- 200-301-GS6
- Additional Names:
- HBG1|mouse anti-HbF antibody, mouse anti-hemoglobin antibody, Gamma-1-globin, Hb F Agamma, Hemoglobin gamma-1 chain, Hemoglobin gamma-A chain, HBG1, HBG2, HbF Antibody, Sickle Cell Disease (SCD)
- Application:
- ELISA, Lateral Flow Assay, Western Blot
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- CE/IVD:
- RUO
- translate.label.attr.clone:
- 4B3.B5.F3.B7
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- HbF antibodies detect the hemoglobin gamma isoform subunit. Functional alternate hemoglobin (Hb) is a hetero tetramer composed of 2 alpha and 2 gamma subunits (alpha-2 gamma-2). Hemoglobin F is elevated in newborns, reaching adult levels by 12 months. HbF levels are increased to as much as 5% to 10% in normal pregnancy. Sickle cell disease (SCD), thalassemias and hemoglobinopathies occur when aberrant forms of hemoglobin are expressed in children and adults. Hemoglobin variants arise from mutations in the globin genes and sickle cell disease and the more benign sickle cell trait are observed in more than 100 million people globally. HbF antibody does not react other forms of Hb. This antibody is ideal for investigators involved in Cardiovascular and developmental biology research.
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Host:
- Mouse
- Immunogen:
- Anti-Hemoglobin beta F Monoclonal Antibody was produced in mice by repeated immunizations with synthetic peptide corresponding to amino acid residues near the N-terminus of Hb B Beta-subunit conjugated to KLH.
- Isotype:
- IgG1, IgG1, kappa
- Physical State:
- Liquid
- Reactivities:
- Human
- Shipping Conditions:
- Dry Ice
- Specificity:
- This protein A purified mouse monoclonal antibody reacts specifically with human HbF gamma isoform. Anti-HbF is purified from tissue culture supernatant by protein A purification. Blast analysis shows 100% homology to Human, Pan troglodytes, Pan paniscus, Gorilla gorilla gorilla, Hylobates lar, Macaca nemestrina, Macaca mulatta, Pongo pygmaeus, Pongo pygmaeus, Macaca fuscata fuscata, and Papio cyn
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Rockland Inc
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.rockland.com/search/?searchString=200-301-GS6
