Biotinylated Human B7-H7 / HHLA2 Protein, Fc,Avitag[TM] Citation Available Product Size(s) 25 ug £382.00 B77-H82F5-25UG Add to order Added to order 200 ug £1582.00 B77-H82F5-200UG Add to order Added to order Academic Pricing Please contact us for academic pricing. Contact Us About this Product SKU: B77-H82F5 Additional Names: B7 Homolog 7|B7-H7|HHLA2 Buffer: Tris with Glycine, Arginine and NaCl, pH7.5 Conjugate: Biotin Extra Details: B7-H7 (HHLA2) is a newly identified B7 family member that regulates human T-cell functions. B7-H7 was previously known as human endogenous retrovirus-H long terminal repeat associating 2 (HHLA2) with unidentified function. Recently, B7-H7 has been identified as a specific ligand for human CD28H. The B7-H7-CD28H pathway strongly promoted CD4+ T-cell proliferation and cytokine production via an AKT-dependent signaling cascade in the presence of TCR signaling, suggesting B7-H7 comprises a new co-stimulatory pathway. The first IgV domain of B7-H7, which presumably binds to a putative receptor, shows the highest homology to other B7 family members. Molecular Weight: 65.9 kDa Physical State: Powder Shipping Conditions: Ambient Storage Conditions: -20[o]C Supplier: ACRO Biosystems Type: Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein Epitope Tag: AviTag™, Fc Tag Long Description: B7-H7 (HHLA2) is a newly identified B7 family member that regulates human T-cell functions. B7-H7 was previously known as human endogenous retrovirus-H long terminal repeat associating 2 (HHLA2) with unidentified function. Recently, B7-H7 has been identified as a specific ligand for human CD28H. The B7-H7-CD28H pathway strongly promoted CD4+ T-cell proliferation and cytokine production via an AKT-dependent signaling cascade in the presence of TCR signaling, suggesting B7-H7 comprises a new co-stimulatory pathway. The first IgV domain of B7-H7, which presumably binds to a putative receptor, shows the highest homology to other B7 family members. Accession: NP_009003.1 Biotinylated Human B7-H7, Fc,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%. Immobilized Human CD28H, Fc Tag (Cat. No. CDH-H5251) at 5 ug/mL (100 uL/well) can bind Biotinylated Human B7-H7, Fc,Avitag (Cat. No. B77-H82F5) with a linear range of 5-78 ng/mL (QC tested). Need Help? View product citations for antibodies B77-H82F5 on CiteAb