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Biotinylated Human B7-H7 / HHLA2 Protein, Fc,Avitag[TM]

Product Size(s)
25 ug
£382.00
B77-H82F5-25UG
200 ug
£1582.00
B77-H82F5-200UG
Academic Pricing
Please contact us for academic pricing.
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About this Product
SKU:
B77-H82F5
Additional Names:
B7 Homolog 7|B7-H7|HHLA2
Buffer:
Tris with Glycine, Arginine and NaCl, pH7.5
Conjugate:
Biotin
Extra Details:
B7-H7 (HHLA2) is a newly identified B7 family member that regulates human T-cell functions. B7-H7 was previously known as human endogenous retrovirus-H long terminal repeat associating 2 (HHLA2) with unidentified function. Recently, B7-H7 has been identified as a specific ligand for human CD28H. The B7-H7-CD28H pathway strongly promoted CD4+ T-cell proliferation and cytokine production via an AKT-dependent signaling cascade in the presence of TCR signaling, suggesting B7-H7 comprises a new co-stimulatory pathway. The first IgV domain of B7-H7, which presumably binds to a putative receptor, shows the highest homology to other B7 family members.
Molecular Weight:
65.9 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
Epitope Tag:
AviTag™, Fc Tag
Long Description:
B7-H7 (HHLA2) is a newly identified B7 family member that regulates human T-cell functions. B7-H7 was previously known as human endogenous retrovirus-H long terminal repeat associating 2 (HHLA2) with unidentified function. Recently, B7-H7 has been identified as a specific ligand for human CD28H. The B7-H7-CD28H pathway strongly promoted CD4+ T-cell proliferation and cytokine production via an AKT-dependent signaling cascade in the presence of TCR signaling, suggesting B7-H7 comprises a new co-stimulatory pathway. The first IgV domain of B7-H7, which presumably binds to a putative receptor, shows the highest homology to other B7 family members.
Accession:
NP_009003.1
Biotinylated Human B7-H7, Fc,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Human CD28H, Fc Tag (Cat. No. CDH-H5251) at 5 ug/mL (100 uL/well) can bind Biotinylated Human B7-H7, Fc,Avitag (Cat. No. B77-H82F5) with a linear range of 5-78 ng/mL (QC tested).