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Cancer Cell Metabolism


NHI-2 is a selective inhibitor of Lactate Dehydrogenase A (LDHA) – IC50 
in vitro = 14.7 µM (NADH), 10.5 µM (Pyruvate)1,2


Product Base Number: 10-4555       Size: 10mg     Size: 50mg


Potent and selective inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH),
IC50=33 µM.3

Product Base Number: 10-1588       Size: 5mg     Size: 25mg


AGI-5198 is a potent (IC50 = 70 nM) inhibitor of R132H mutant isocitrate dehydrogenase 1(IDH1).4

Product Base Number: 10-4599       Size: 5mg     Size: 25mg


MF-438 is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) - IC50 = 2.3 nM.5

Product Base Number: 10-4558       Size: 5mg     Size: 25mg


Cytotoxic agent that alters phospholipid biosynthesis via inhibition of CTP: choline-phosphate cytidylyltransferase.6,7

Product Base Number: 10-4560       Size: 5mg     Size: 25mg


R162 is a selective inhibitor of Glutamate Dehydrogenase 1. Selective over 6-phosphogluconate and fumarate hydratase.8

Product Base Number: 10-4603       Size: 10mg     Size: 50mg


Lonidamine is a mitochondrial hexokinase inhibitor.9  The disruption of mitochondrial transmembrane potential has also been linked to its apoptotic effects.10

Product Base Number: 10-4563       Size: 10mg     Size: 50mg


PFK15 is a selective inhibitor of 6-Phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3), an enzyme that is constitutively expressed in neoplastic cells and is required for the high glycolytic rate (Warburg effect) of these cells.11,12,13

Product Base Number: 10-4580       Size: 5mg     Size: 25mg


CB-839 is a potent (IC50 = 24 nM) inhibitor of glutaminase (KGA and GAC).14,15

Product Base Number: 10-4556       Size: 5mg     Size: 25mg