Cancer Cell Metabolism

NHI-2

NHI-2 is a selective inhibitor of Lactate Dehydrogenase A (LDHA) – IC50 
in vitro = 14.7 µM (NADH), 10.5 µM (Pyruvate)^1,2

Product Base Number: 10-4555       Size: 10mg     Size: 50mg

CBR-5884

Potent and selective inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH),
IC₅₀=33 µM.³

Product Base Number: 10-1588       Size: 5mg     Size: 25mg

AGI-5198

AGI-5198 is a potent (IC₅₀ = 70 nM) inhibitor of R132H mutant isocitrate dehydrogenase 1(IDH1).⁴

Product Base Number: 10-4599       Size: 5mg     Size: 25mg

MF-438

MF-438 is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) - IC₅₀ = 2.3 nM.⁵

Product Base Number: 10-4558       Size: 5mg     Size: 25mg

CT-2584

Cytotoxic agent that alters phospholipid biosynthesis via inhibition of CTP: choline-phosphate cytidylyltransferase.^6,7

Product Base Number: 10-4560       Size: 5mg     Size: 25mg

R162

R162 is a selective inhibitor of Glutamate Dehydrogenase 1. Selective over 6-phosphogluconate and fumarate hydratase.⁸

Product Base Number: 10-4603       Size: 10mg     Size: 50mg

Lonidamine

Lonidamine is a mitochondrial hexokinase inhibitor.⁹  The disruption of mitochondrial transmembrane potential has also been linked to its apoptotic effects.¹⁰

Product Base Number: 10-4563       Size: 10mg     Size: 50mg

PFK15

PFK15 is a selective inhibitor of 6-Phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3), an enzyme that is constitutively expressed in neoplastic cells and is required for the high glycolytic rate (Warburg effect) of these cells.^11,12,13

Product Base Number: 10-4580       Size: 5mg     Size: 25mg

CB-839

CB-839 is a potent (IC50 = 24 nM) inhibitor of glutaminase (KGA and GAC).^14,15

^{Product Base Number: 10-4556       Size: 5mg     Size: 25mg}