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Neuronal Cell Lines for Neurodegenerative Research

2BScientific's Ranges for Neuronal Cell Lines in Neurodegenerative Research

2BScientific's Neuronal Cell Lines

Understanding the complexities of neurodegenerative diseases requires reliable and high-quality in vitro models. Our diverse selection of neuronal and glial cell lines supports a wide range of research applications, from disease modelling to drug discovery. Whether you need differentiated neurons, microglia for inflammation studies, or fluorescent-labelled options for advanced imaging, our collection provides reproducible, validated, and physiologically relevant solutions.

2BScientific's Neuronal Cell Lines

SH-SY5Y Cells (Human-derived neuronal cell line):

These are used for studying Alzheimer’s disease, Parkinson’s disease, and neurotoxicity. They can be differentiated into neuron-like cells for neurodegenerative studies. Variants that are available are:

PC12 Cells (Rat adrenal pheochromocytoma-derived cell line): Commonly used for studying neuronal differentiation and function responds to nerve growth factor (NGF) by differentiating into neuron-like cells. The available variant is the

Pluripotent Stem Cells for Neurodegenerative Disease Models

Induced Pluripotent Stem Cells (iPSCs) (Human-derived, reprogrammable stem cells)- link TBC 

  • Can be differentiated into neurons and glial cells for a more physiologically relevant model.

C57BL/6 Mouse Cortical Neurons:

Isolated from E18 mouse brain cortex, these primary cortical neurons are ideal for studies on neurodevelopment and neurodegenerative diseases.

Widely used in neuroscience research to study neural development, differentiation, neurotoxicity, cell signalling pathways, and axonal growth. Derived from the neural crest, these cells are known for their rapid growth and ability to differentiate into neuron-like cells under specific conditions.

Commonly employed in studies of neurodegenerative disorders and testing potential neuroprotective therapies. An immortalised subclone derived from HT4 cells of the mouse hippocampus, are pivotal in neuropharmacological research.

These cells are utilised in neurological research, particularly in studies related to neurodegenerative diseases and neurobiology. Derived from the central nervous system, these cells offer a human-based model for investigating neural processes and disease mechanisms.

Glial Cells: Supporting and Protecting Neurons

  • Astrocytes (Essential for brain homeostasis and neuronal function): These star-shaped cells regulate synaptic activity, support neuronal survival, and maintain the blood-brain barrier. Range of available Variants are:
  • Microglia (Resident immune cells of the central nervous system)

Critical for clearing debris, responding to injury, and modulating neuroinflammation. In neurodegenerative conditions, microglia can become chronically activated, contributing to neuronal damage. Some of the available cell lines are:

  1. Immortalized Human Microglia Cells (Innoprot Cardiac Cell System)
  2. Microglia Medium Kit (Innoprot Cell Culture Medium Kit)
  • Oligodendrocytes (Essential for myelination and neuron protection)- TBC the link 

Responsible for producing myelin, ensuring efficient signal transmission in the nervous system. Dysfunction in oligodendrocytes is linked to diseases such as Multiple Sclerosis (MS) and other neurodegenerative disorders.