Rhodopsin Antibody, Clone 4D2: RPE
Product Sizes
100 ug
SMC-176D-RPE-100UG
About this Product
- SKU:
- SMC-176D-RPE
- Additional Names:
- OPN2 Antibody, opsd Antibody, opsin 2 Antibody, opsin 2 rod pigment Antibody, opsin2 Antibody, RHO Antibody, RP4 Antibody, MGC138309 Antibody, Retinitis Pigmentosa 4 Antibody
- Application:
- ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
- Buffer:
- PBS
- CE/IVD:
- RUO
- translate.label.attr.clone:
- 4D2
- Clonality:
- Monoclonal
- Conjugate:
- R-PE
- Concentration:
- 1 mg/ml
- Extra Details:
- Rhodopsin consists of the protein moiety opsin and a reversibly covalently bound cofactor, retinal. Opsin, a bundle of seven membrane embedded alpha-helices, binds retinal, a photo reactive chromophore, in a central pocket (2, 3). In addition to being the pigment of the retina that is responsible for both the formation of the photoreceptor cells, its function is to specifically convey information stored in the specific geometry of the chormophore to the surface of the molecule upon light absorption (2). In the active state, rhodopsin activates transduction, a GTP binding protein. Once activated, transduction promotes the hydrolysis of cGMP by phosphodiesterase. Rhodopsin's activity is believed to be shut off by its phosphorylation followed by binding of the soluble protein arrestin (4). Mutations in the rhodopsin gene lead to retinitis pigmentosa, which can be inherited as an autosomal dominant, an autosomal recessive or an X-linked recessive disorder (5).
- Host:
- Mouse
- Immunogen:
- Bovine Rhodopsin
- Isotype:
- IgG1
- Purification:
- Protein G Purified
- Reactivities:
- Amphibian, Avian, Bovine, Fish, Human, Mouse
- Shipping Conditions:
- Blue Ice
- Specificity:
- Detects ~40kDa. Binds specifically to the N-terminus of Rhodopsin. Does not detect Rhodopsin in invertebrates.
- Storage Conditions:
- See Manual
- Supplier:
- StressMarq Biosciences
- Type:
- Antibody: Monoclonal Antibody
