HGF Activator Inhibitor Type 1 (HAI-1)
Product Sizes
100 ug
£674.12
103-M229-100UG
About this Product
- SKU:
- 103-M229
- Additional Names:
- Spint1; HAI-1
- Application:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 3G21
- Clonality:
- Monoclonal
- Extra Details:
- Hepatocyte growth factor activator inhibitor1 (HAI1) encoded by the Spint1 gene is a Kunitz-type serine protease inhibitor, identified as a strong inhibitor of HGF activator (HGF-A) and matripas. The membraneanchored HAI1 consists of two Kunitz domains, a LDL-recepto-rlike domain, and a C-terminal transmembrane domain. Two soluble forms are generated by ectodomain shedding, one with a single Kunitz domain and the other with two Kunitz domains. HAI1 is not only an inhibitor but also a specific receptor of active HGFA, acting as a reservoir of this enzyme on the cell surface. The shedding of HAI1 and HGFA/HAI1 complex is enhanced by treatment with phorbol 12myristate, 13acetate or IL1B Beta. The regulated shedding is completely inhibited by a synthetic zinc metalloprotease inhibitor.
- Formulation:
- lyophilized
- Host:
- Rat
- Immunogen:
- recombinant mouse HAI-1 extracellular domain
- Isotype:
- IgG2
- Purification:
- Protein G/A chromatography
- Reactivities:
- Mouse
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody