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Antibodies

Anti-Human CD196/CCR6 Monoclonal Antibody(APC Conjugated)

Product Sizes
Anti-Human CD196/CCR6 Monoclonal Antibody(APC Conjugated)
RD21846F-100TESTS
Academic Pricing
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About this Product
SKU:
RD21846F-100TESTS
Additional Names:
CKRL3, CMKBR6, GPR29, STRL22,GPRCY4
Application:
Flow Cytometry
Buffer:
PBS with 0.05% Proclin300, 1% BSA
translate.label.attr.clone:
G034E3
Clonality:
Monoclonal
Conjugate:
APC
Extra Details:
CCR6, also known as CD196/CCR6, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the B Beta defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.
Gene Details:
CCR6
Host:
Mouse
Isotype:
IgG2b, kappa
Protein Details:
P51684
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
2-8[o]C Do not freeze. Protect from light.
Size:
100 tests
Supplier:
Reddot
Type:
Antibody: Monoclonal Antibody
Synonyms:
BN-1;C-C chemokine receptor type 6;C-C CKR-6;CC-CKR-6;CCR-6;CD196;chemokine (C-C motif) receptor 6;chemokine (C-C) receptor 6;chemokine receptor-like 3;CKRL3;CKR-L3;CMKBR6;DCR2;DRY6;G protein-coupled receptor 29;GPR29;GPRCY4;GPR-CY4;G-protein coupled receptor 29;LARC receptor;seven-transmembrane receptor, lymphocyte, 22;STRL22