anti-Keratin K8/K18 NCL-5D3, mouse monoclonal antibody
Product Sizes
1 ml
£370.00
10502-1ML
About this Product
- SKU:
- 10502
- Additional Names:
- Keratin, type II cytoskeletal 8, Cytokeratin-8, CK-8, Keratin-8, K8, Type-II keratin Kb8, KRT8, CYK8
- Application:
- Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
- CE/IVD:
- RUO
- translate.label.attr.clone:
- NCL-5D3
- Clonality:
- Monoclonal
- Extra Details:
- The antibody recognizes all simple epithelia including glandular epithelia. It does not react with stratified squamous epithelium. Useful for the differentiation between carcinomas and lymphomas. In immunoblotting (Western) NCL 5D3 is directed against the the 52.2 kDa keratin K8 (originally reported also to 45 kDa keratin K18; formerly also designated cytokeratins according to the Moll-catalogue). Epitope has been mapped to aa 353-367 on alpha helical rod domain of keratin K8 (Waseem et al., 2004). Positive control: glandular epithelium. Waseem A, Karsten U, Leigh IM, Purkis P, Waseem NH, Lane BE: Conformational changes in the rod domain of human keratin 8 following heterotypic association with keratin 18 and its implication for filament stability. Biochemistry 43, 1283-1295 (2004).
- Formulation:
- Contains 0.1% sodium azide
- Host:
- Mouse
- Immunogen:
- Isolated from human breast cancer carcinoma cell line MCF-7
- Isotype:
- IgG1
- Purification:
- Hybridoma cell culture supernatant
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Progen
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:10502
