Anti-Hu CD54 PE
Product Sizes
100 tests
AFC-TMGYJC-100TESTS
About this Product
- SKU:
- AFC-TMGYJC
- Additional Names:
- ICAM-1, BB2, P3.58
- Application:
- Flow Cytometry
- Buffer:
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- translate.label.attr.clone:
- MEM-111
- Clonality:
- monoclonal
- Conjugate:
- PE
- Extra Details:
- CD54 (ICAM-1) is a 90 kD member of the C2 subset of immunoglobulin superfamily. It is a transmembrane molecule with 7 potential N-glycosylated sites, expressed on resting monocytes and endothelial cells and can be upregulated on many other cells, e.g. with lymphokines, on B- and T-lymphocytes, thymocytes, dendritic cells and also on keratinocytes, chondrocytes, as well as epithelial cells. CD54 mediates cell adhesion by binding to integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1). The interaction of CD54 with LFA-1 enhances antigen-specific T-cell activation.
- Format:
- PE
- Immunogen:
- Raji human Burkitt's lymphoma cell line
- Isotype:
- IgG2a
- Purification:
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Research Area:
- Immunology
- Shipping Conditions:
- Blue Ice
- Specificity:
- The antibody MEM-111 reacts with an extracellular epitope of CD54 (ICAM-1), a 85-110 kDa type I transmembrane glycoprotein (receptor for rhinovirus). The expression of CD54 is upregulated by activation; it is expressed on activated endothelial cells, T lymphocytes, B lymphocytes, monocytes, macrophages, granulocytes and dendritic cells.
- Storage Conditions:
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
- Supplier:
- Nordic BioSite
- Manufacturer's Data Sheet:Anti-Hu CD54 PE
