Purified Anti-PtdIns(3 4 5)P3 IgG
Product Sizes
50 ug
ECH-Z-P345B-50UG
250 ug
ECH-Z-P345B-250UG
About this Product
- SKU:
- ECH-Z-P345B
- Clonality:
- Monoclonal
- Extra Details:
- Purified Anti-PtdIns(3 4 5)P3 monoclonal antibody.Subclass: IgG1Source: MouseApplications: ELISA Alphascreen Fluorescence Polarization Protein-Lipid Overlay (PIP Strip)Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3 4 5-trisphosphate (PIP3) formed from PI(4 5)P2 though phosphorylation by PI 3-kinase activates numerous signaling pathways resulting in cell proliferation growth survival glucose transport and protein synthesis. High PIP3 levels from dysregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4 5)P2 and SHIP to PI(3 4)P2. Powered by Bioz See more details on BiozFeatured in Publications1) Sweeney G. R. R. Garg et al. (2004). "Intracellular delivery of phosphatidylinositol (3 4 5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake." J Biol Chem 279(31): 32233-42.2) Papakonstanti E. A. A. J. Ridley et al. (2007). "The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN." Embo J 26(13): 3050-61.3) Maffucci T. C. Raimondi et al. (2009). "A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation." PLoS One 4(12): e8285.4) Wang Y. L. M. Weiss et al. (2010). "Coordinate control of host centrosome position organelle distribution and migratory response by Toxoplasma gondii via host mTORC2." J Biol Chem 285(20): 15611-8.Product keywords: PIP3 PI(3 4 5)P3 PtdIns(3 4 5)P3 IgG anti-PIP3
- Immunogen:
- ptdins(3 4 5)p3
- Isotype:
- IgG, IgG1
- Purification:
- Purified
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- Echelon Biosciences
- Type:
- Antibody: Monoclonal Antibody