CD40LG Recombinant Protein (Human)
Product Sizes
10 ug
OPED00085-10UG
About this Product
- SKU:
- OPED00085
- Additional Names:
- 30 kDa adipocyte complement-related protein;30kDa;a;Acd;Acdc;Acr;Acrp30;Ad;Adid;adip;adipo;adipocyte complement related protein;adipocyte complement-related 30 kDa protein;adipocyte, C1Q and collagen domain containing;adipocyte, C1q and collagen domain-containing protein;adipocyte-specific protein AdipoQ;adiponectin;adiponectin d;ap;apM1;APN;CD154;CD40 antigen ligand;CD40 ligand;CD40L;CD40-L;GBP2;GBP28;gp39;hCD40L;HIGM1;IGM;IMD3;T-B cell-activating molecule;T-BAM;T-cell antigen Gp39;TNF-related activation protein;TNFSF5;TRAP;tumor necrosis factor (ligand) superfamily member 5;Tumor necrosis factor ligand superfamily member 5.|adiponectin, C1Q and collagen domain containing|CD40 ligand
- Buffer:
- Lyophilized. Contains PBS.
- Extra Details:
- Cytokine that binds to CD40/TNFRSF5 (PubMed:1280226). Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching (By similarity).|Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
- Formulation:
- Lyophilized. Contains PBS.
- Immunogen:
- Adipoq|CD40LG
- Molecular Weight:
- 38 kDa
- Physical State:
- Lyophilized
- Purity:
- >90%
- Purification:
- Purified
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- CHO Cells
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
