Anti-Glial Fibrillary Acidic Protein (GFAP)
Product Sizes
100 ul
OAPC00114-100UL
About this Product
- SKU:
- OAPC00114
- Application:
- Immunofluorescence, Western Blot
- Buffer:
- Liquid. 100 ul neat serum.
- Clonality:
- Polyclonal
- Extra Details:
- Glial Fibrillary Acidic Protein (GFAP) was discovered by Amico Bignami and co-workers as a major fibrous protein of multiple sclerosis plaques (1). It was subsequently found to be a member of the 10nm or intermediate filament (IF) family, specifically the IF family Class III, which also includes peripherin, desmin and vimentin. GFAP is strongly and specifically expressed in astrocytes and certain other astroglia in the CNS, in satellite cells, peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In many damage and disease states GFAP expression is heavily upregulated in astrocytes. In addition, neural stem cells frequently strongly express GFAP. Point mutations in the protein coding region of the GFAP gene lead to Alexander disease which is characterized by the presence of abnormal astrocytes containing GFAP protein aggregates known as Rosenthal fibers (2).
- Formulation:
- Liquid. 100 ul neat serum.
- Host:
- Rabbit
- Immunogen:
- Recombinant and purified bovine GFAP.
- Molecular Weight:
- ~50kDa
- Physical State:
- Liquid
- Purification:
- Unpurified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Specificity:
- Specific for the ~50kDa GFAP protein. A lower band at ~45kDa is a proteolytic fragment derived from the GFAP molecule. The antibody has been directly tested for reactivity in human, mouse and rat. It is expected that the antibody will react with other mammalian tissues.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Aviva Systems Biology
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
