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Antibodies

anti-CDC73 / Parafibromin antibody

Product Sizes
100 ul
ARG59493-100UL
Academic Pricing
Please contact us for academic pricing.
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About this Product
SKU:
ARG59493
Additional Names:
Hyperparathyroidism 2 protein; HRPT2; HRPT1; HYX; Cell division cycle protein 73 homolog; HPTJT; Parafibromin; C1orf28; FIHP
Application:
Flow Cytometry, IHC-Paraffin, Immunocytochemistry, Immunofluorescence
Buffer:
PBS and 0.09% (W/V) Sodium azide.
CE/IVD:
RUO
Clonality:
Polyclonal
Extra Details:
This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009]
Host:
Rabbit
Immunogen:
KLH-conjugated synthetic peptide between aa. 132-161 of Human CDC73 / Parafibromin.
Isotype:
IgG
Purification:
Affinity Purified; Protein A Purified
Reactivities:
Avian, Human, Mouse, Rat
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C
Supplier:
Arigo Biolaboratories
Type:
Antibody: Polyclonal Antibody
Flow Cytometry: U-2OS cells were fixed with 2% paraformaldehyde (10 min) and then permeabilized with 90% methanol for 10 min. The cells were then incubated in 2% BSA to block non-specific protein-protein interactions followed by ARG59493 anti-CDC73 / Parafibromin antibody (right histogram) at 1:25 dilution for 60 min at 37°C, followed by DyLight®488 labelled secondary antibody. Isotype control antibody (left histogram) was Rabbit IgG (1 ug/10^6 cells) used under the same conditions. Acquisition of > 10000 events was performed.
Immunofluorescence: HeLa cells stained with ARG59493 anti-CDC73 / Parafibromin antibody (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).
Immunohistochemistry: Paraformaldehyde-fixed and paraffin-embedded Human adrenal gland blocked with 3% BSA for 0.5 hour at RT. Antigen Retrieval: Heat mediated was performed in Citrate buffer (pH 6.0). Samples were incubated with ARG59493 anti-CDC73 / Parafibromin antibody at 1:25 for 1 hours at 37°C.