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Exalpha / Nordic Mubio

Exalpha was founded over 20 years ago by a group of scientists dedicated to accelerating the pace of discovery in the life science arena by rapidly developing and marketing unique products at the forefront of science. In order to develop great products, you have to ask the right questions when you start. Where some companies are satisfied with ‘average’, ‘good enough’ or ‘me too’ products, Exalpha only settles for products that answer the pertinent questions. Exalpha continually monitors scientific trends and recent literature, we strive to produce products that answer real needs. Exalpha has a long history of developing uniquely superior products that simply perform well, allowing researchers to focus on the task at hand and not on the quality of a supplier’s products.

Exalpha / Nordic Mubio

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Eggcellent Antibodies
 

Chicken IgY - Why use Chickens?

  • Chickens are not mammals and therefore are more apt to make high-avidity antibodies to mammalian antigens (especially highly conserved mammalian proteins).
  • To our knowledge, it is the most humane way to produce polyclonal antibodies. There is no need to bleed the chicken. Simply collect the eggs.
  • A single chicken can produce an enormous amount of antibody, up to 3 grams of IgY per month, which is 10-20 times the amount of a rabbit. Furthermore, compared to rabbits, chickens produce antibody much quicker.
  • Fc region of chicken IgY is sufficiently different from mammalian IgG:
  • Reduces background by not binding to mammalian rheumatoid factors or other naturally occurring anti-mammalian antibodies (e.g. HAMA).
  • Does not activate mammalian complement systems.

To our knowledge, it is the most humane way to produce polyclonal antibodies. There is no need to bleed the chicken. Simply collect the eggs

  • To our knowledge, it is the most humane way to produce polyclonal ant Does not bind to mammalian Fc receptors.
  • Does not bind to standard immunoglobulin-binding proteins such as protein A (Staphylococcus aureus), protein G (Streptococcus sp.), or protein L (Peptostreptococcus magnus).
  • IgY is a stable antibody and may be enzyme-labeled, biotinylated and gold–labeled by standard procedures.

Gallus brand has over 100 Chicken polyclonal primary antibodies...

  • Epitope Tags
  • Food Proteins
  • Fusion Proteins
  • Human Immunoglobulins and Proteins
  • Mammalian Immunoglobulins and Proteins
  • Microbial Antigens

Protein A, Protein G or Protein L

.. and over 100 secondary antibodies:

The Gallus range of secondary antibodies are produced in chicken against a wide range of mammalian targets including Bovine, Cervid, Rat, Dog, Horse, Human, Mouse, Pig, Rabbit and Sheep (detecting IgG heavy and light chains, Fc region, Fab fragments, IgM and Light chains (Lambda and Kappa). Gallus also have a range of anti Chicken IgY, IgM and IgA antibodies (detecting heavy and light chains, Fab or Fc) for use with their chicken primary antibodies.

Finally…

  • Antibodies conjugated to multiple labels including Biotin, FITC, horseradish peroxidase, agarose.
  • Range of control antibodies eg, Normal Goose IgY, Normal Chicken IgY
  • Kits: EggsPress IgY purification kits for customers to purify their own antibodies from chicken eggs.
  •  Custom services available: IgY production in Chicken, IgY purification, Affinity purification if required and peptide synthesis.

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