|The Five Immunoglobulin (Ig) Classes
|Number of antigen-binding sites
|Molecular weight (Daltons)
|Percentage of total antibody in serum
||The main antibody within the primary immune response, the monomer form of IgM serves as the B cell receptor.
||The main blood antibody of secondary responses neutralises toxins.
||Secreted into saliva, tears, mucus, and colostrum.
||Antibody utilised in allergy and antiparasitic responses.
||B cell receptor.
Antitoxins are a sub-group of antigens which can neutralise a toxic substance most efficiently, similarly to antibodies, each antitoxin is able to neutralise a specific toxin, they can additionally kill bacteria as well as other foreign microorganisms. Antitoxins for human application are often developed by injecting a horse with a small amount of toxin repeatedly, this results in antitoxin build-ups within blood cells which can be extracted as the antiserum. These serums can be used to treat a range of diseases including botulism, diphtheria, gas gangrene, tetanus, and dysentery [3,4].
Antibodies have a range of medical and scientific applications, this includes diagnosis, therapy, and research. Immunodiagnostic techniques such as ELISA require antibodies to detect the presence of infection-causing antigens. In addition to this, the detection of specific antibodies can demonstrate the presence of ailments such as hepatitis, in this case, an elevation in the number of IgM antibodies. With regards to therapy, monoclonal antibodies are utilised to treat a variety of diseases including multiple sclerosis, psoriasis, and breast cancer .
Antibodies have a huge potential in biomedical research, for example, western blotting utilises specific labelled antibodies to detect the presence of specific proteins. Immunohistochemistry and immunocytochemistry also utilise antibodies to bind to target antigens and detect the localisation via chromogenic detection with a coloured enzyme dye, or fluorescent detection with a fluorescent dye [6,7].
Finding the right antibody for the desired experiment is crucial in getting the desired results from the study or experiment. There are a range of variables that must be matched to the antibody such as the nature of the sample, this includes investigations into the desired region for detection, what processes samples will undergo before the use of antibodies and the species that synthesized the sample you wish to utilise the antibody alongside. There is a range of external websites that allow for easy selection of antibodies for the experiment, for example, Absolute Antibody allows you to find the desired primary and recombinant antibodies via the experiment or process of elimination.
2BScientific has a range of products, including a selection of antibodies and antigens, be sure to utilise the filters on the left side of the site to narrow down the options. 2BScientific is passionate about ensuring that customers get the precise, required product and have a friendly and knowledgeable team ready to answer any technical queries.