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Antibodies

ADO Polyclonal Antibody

Product Sizes
ADO Polyclonal Antibody
RD78396A-120UL
Academic Pricing
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About this Product
SKU:
RD78396A-120UL
Additional Names:
2 aminoethanethiol dioxygenase,2-aminoethanethiol dioxygenase,ADO 2 aminoethanethiol (cysteamine) dioxygenase,ADO,AEDO,C10orf22,Chromosome 10 open reasing frame 22,cysteamine (2-aminoethanethiol) dioxygenase (ADO),Cysteamine dioxygenase,DKFZp564C046,FLJ14547
Application:
ELISA, Immunohistochemistry, Western Blot
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Clonality:
Polyclonal
Concentration:
0.3 mg/ml
Extra Details:
Human thiol dioxygenases include cysteine dioxygenase (CDO, MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO, EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine. Mouse Ado has strong and specific dioxygenase activity in vitro towards cysteamine but not cysteine. Recombinant Ado was shown to bind iron. Overexpression of Ado in HepG2/C3A cells increased the production of hypotaurine from cysteamine. Similar results were found with human ADO. When endogenous expression of ADO was reduced by RNA-mediated interference, hypotaurine production decreased. The demonstration of high levels of ADO in brain challenges the previous assumption that most of the taurine in the brain is a consequence of CDO activity.
Host:
Rabbit
Immunogen:
Synthetic peptide of human ADO
Isotype:
IgG
Protein Details:
Q96SZ5
Purification:
Affinity Purified
Reactivities:
Human, Mouse
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C Avoid freeze/thaw cycles.
Size:
120 ul
Supplier:
Reddot
Type:
Antibody: Polyclonal Antibody
Synonyms:
Cysteamine dioxygenase