APC Anti-Mouse CD22 Antibody[Cy34.1]
Product Sizes
25 ug
E-AB-F1021UE-25UG
100 ug
E-AB-F1021UE-100UG
About this Product
- SKU:
- E-AB-F1021UE
- Additional Names:
- Siglec2;B-cell receptor CD22;B-lymphocyte cell adhesion molecule;BL-CAM;CD22;Cd22;Lyb-8;Sialic acid-binding Ig-like lectin 2;Siglec-2;T-cell surface antigen Leu-14
- Application:
- Flow Cytometry
- Buffer:
- PBS
- translate.label.attr.clone:
- Cy34.1
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Concentration:
- 0.2 mg/ml
- Extra Details:
- The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig u chain are augmented in the presence of Cy34.1 mAb.
- Host:
- Mouse
- Immunogen:
- CD22
- Isotype:
- IgG1, kappa
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C Do not freeze. Protect from light.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:1W5yL0