HSP90 alpha Protein
Product Sizes
50 ug
£221.00
SPR-101-50UG
100 ug
£329.00
SPR-101-100UG
About this Product
- SKU:
- SPR-101
- Additional Names:
- HSP90AA1, HSP90-alpha, HSP90A, HSPCA, HSPC1, Heat shock protein HSP 90-alpha, Heat shock 90 kDa protein 1 alpha isoform, HSPCAL3, HSP86, HSP89A, HSP90Alpha
- Application:
- Cell-based/Functional Assay, Detection/Quantitation, SDS-PAGE, Surface Plasmon Resonance, Western Blot
- Buffer:
- 50mM Tris/HCl pH7.5, 5mM Bme, 0.3M NaCl, 10% glycerol
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
- Extra Details:
- HSP90 alpha is a highly conserved molecular chaperone that plays a central role in maintaining protein homeostasis under both normal and stress conditions. In the context of neuroscience, HSP90 alpha is increasingly recognized for its involvement in the folding, stabilization, and functional regulation of key neuronal proteins, including kinases, transcription factors, and hormone receptors. In neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's, the accumulation of misfolded proteins and impaired proteostasis are hallmark features. HSP90 alpha contributes to the cellular defense against these pathologies by stabilizing client proteins and preventing their aggregation. However, its chaperone activity can also inadvertently preserve the function of pathogenic proteins, such as hyperphosphorylated tau or mutant huntingtin, thereby influencing disease progression. HSP90 alpha forms dynamic complexes with co-chaperones like Cdc37 and p23, modulating the fate of its client proteins. Pharmacological inhibition of HSP90 alpha has shown promise in preclinical models by promoting the degradation of neurotoxic proteins and restoring proteostasis.
- Immunogen:
- HSP90 alpha Protein
- Molecular Weight:
- ~90 kDa
- Purity:
- >90%
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/protein/hsp90-alpha-protein-spr-101/
